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Cornea & External Diseases

















Bilateral corneal verticillata in a patient who is treated chronically with amiodarone.

  • Clinical features:
    • Symptoms: the corneal changes are rarely of any visual significance.
    • Signs:
      • Symmetric, bilateral, whorl-like pattern of powdery, white, yellow or brown corneal epithelial deposits
      • Appears in a vortex fashion in the inferocentral cornea and swirls outwards sparing the limbus
  • Occurs in Fabry's disease and in patients being treated with a variety of drugs including amiodarone, chloroquine, amodiaquine, meperidine, indomethacin, chlorpromazine and tamoxifen.

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