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Cornea & External Diseases




















Non Infectious
Superficial Punctate Keratitis of Thygeson

  • Uncommon, non-contagious, primary corneal inflammation of unknown etiology.
  • Clinical features:
    • Symptoms:
      • Patients usually present with bilateral keratitis
      • Characteristic remissions and exacerbations of tearing, foreign body sensation, and photophobia over several years.
    • Signs:
      • Superficial coarse, punctate, discrete gray epithelial opacities which protrude into the tear film
      • More often located centrally
      • Usually remain for several weeks to several months and eventually fade
      • The conjunctiva is not involved.
  • Treatment:
    • Mild symptoms may be treated with simple lubricants.
    • Low dose corticosteroids and topical cyclosporine are usually effective to reduce the duration of the recurrence.

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