Home Search
 

Cornea & External Diseases

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Non Infectious
Coarse epithelial keratitis which is stained with fluorescein dye.
Keratoconjunctivitis sicca (KCS) in two different patients with history of bone marrow transplantations.

  • Common after bone marrow transplantation.
  • Some ocular manifestation such as keratoconjunctivitis sicca (KCS), sterile conjunctivitis, cicatricial lagophthalmos, cataracts and retinal microvascular occlusive disease have commonly observed in patients with GVHD.
  • KCS is the most significant ocular complication associated with acute and chronic GVHD.
  • Clinical features:
    • Symptoms:
      • Foreign body sensation, itching, burning and moderate conjunctival redness
      • Decreased vision, pain and photophobia usually occur in advanced cases
      • Exacerbated by wind, blinking or prolonged reading.
    • Signs:
      • Minimal or absent tear meniscus
      • Mucus threads and conjunctival hyperemia
      • Fine, medium or coarse epithelial keratitis
      • Filamentary keratitis may be found especially in the interpalperal fissure
      • Epithelial erosion, subsequent stromal ulceration and recurrent corneal infections may occur in more severe cases.
  • Complications include corneal scarring, neovascularization or conjunctivalization of the cornea.
  • Management:
    • Vigorous surface lubrication with artificial non-preservativeartificial tears or ointment.
    • Treatment of associated systemic diseases.
    • Punctal occlusion.
    • Humidifiers or moisture chambers to decrease tear film evaporation.
    • Surgical tarsorraphy for intractable dry eye.

Copyright © 2003 Digital Reference of Ophthalmology. All rights reserved. All material published on this website is the property of Digital Reference of Ophthalmology and cannot be duplicated without permission.
Home Search Home Search