- A rare, unilateral premalignant condition
- More commonly seen in older, fair-skinned individuals
- Usually occurs as a localized, slightly elevated, minimally invasive,
and remains confined to the epithelium
- May infrequently invade the underlying stroma and metastasize to
regional lymph nodes
- Recurrences are common
- Clinical features:
- Nodular, or irregular white lesions (leukoplakia) that may
occur anywhere in the conjunctiva or cornea, most commonly at
the limbus in interpalpebral fissure
- Fleshy or frothy vascularized lesions that simulate benign
conjunctival squamous papilloma
- Diffuse, translucent gray area of conjuctival intraepithelial
neoplasia involving the cornea
- Management:
- Surgical excision with cryotherapy and/or alcohol application
- Use of topical chemotherapy with mitomycin C, 5-fluorouracil,
or interferon
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