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Infectious
Acanthamoeba Keratitis

  • Most commonly associated with contact lens use, corneal trauma and history of exposure to possibly contaminated fresh water.
  • Clinical features:
    • Symptoms:
      • Foreign body sensation, severe ocular pain, photophobia and blurred vision
      • Often pain is more severe than signs in early course of the disease
    • Signs:
      • Usually unilateral diffuse punctate epitheliopathy, dendritic epithelial lesion which may gradually progress to stromal infection associated with ring infiltrate formation
      • Enlarged corneal nerve ( keratoneuritis) is patognomonic of the infection
      • Scleritis may be found in advanced cases
  • Management:
    • Early diagnosis a prognostic factor of a successful outcome.
    • Epithelial debridement.
    • Topical anti-amoeba agents.
    • Penetrating keratoplasty in a severe progressive keratitis.

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